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The comparator is SGLT2 initiation

This article is part of our series on the FDAs National Priority Voucher program, exploring the therapies selected, their potential impact, safety considerations, and what accelerated review could mean for patients in the US and globally

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By suppressing appetite and delaying gastric emptying, GLP-1RAs chronically reduce nutrient delivery from the diet [53]

therefore, current interpretations draw on evidence from obesity, aging, and caloric restriction literature