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Often referred to as the "master antioxidant," glutathione is a naturally occurring substance the human body needs to protect its cells from oxidative stress

These peptides activate MRGPRX2, a mast-cell receptor that fires on positively charged, aromatic molecules and releases histamine into the tissue. Sodium and chloride ions screen the peptides positive charge, so the receptor sees less of it and the welt shrinks

The extracellular L-cysteine/L-cystine redox balance, and thus the synthesis of GSH, is finely regulated by the intracellular conversion of L-cystine into L-cysteine (10), and its impairment is related to oxidative stress and other pathological disorders

p = 0.55, Supplementary Fig

It is suggested that glutathione supplements might prove to be useful