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doi:10.1016/j.diabres.2013.11.002 20

These drugs were initially developed for the treatment and/or management of diabetes, but scientists thought this drug could be a direct cure for obesity as well

We aimed to systematically retrieve all currently available RCTs of tirzepatide in individuals with type 2 diabetes and synthesise the evidence by means of clinically relevant meta-analyses for outcomes of efficacy and safety

Crucially, the positive predictive value of elevated amylase and lipase for actual pancreatitis was less than 1%

Sharon G, Cruz NJ, Kang DW, Gandal MJ, Wang B, Kim YM, Zink EM, Casey CP, Taylor BC, Lane CJ, Bramer LM, Isern NG, Hoyt DW, Noecker C, Sweredoski MJ, Moradian A, Borenstein E, Jansson JK, Knight R, Metz TO, Lois C, Geschwind DH, Krajmalnik-Brown R, Mazmanian SK