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If you are pregnant or breastfeeding, our doctors do not recommend it

These include: Large disc extrusions or sequestered fragments requiring surgical intervention Severe spinal stenosis with significant canal narrowing Bone spurs (osteophytes) compressing nerve structures Advanced degenerative disc disease with complete disc height loss Spondylolisthesis (vertebral slippage) beyond grade 1 Cauda equina syndrome (medical emergency requiring immediate surgery) Users with these conditions typically report minimal improvement from peptide therapy alone

In: Borzellino G, Cordiano C (eds) Biliary lithiasis: basic science, current diagnosis and management

Its supposedly a cleaner, simpler way to manage appetite, though questions of safety and trust remain

In the SURMOUNT-3 and SURMOUNT-4 studies, participants experienced significant weight losses with tirzepatide treatment, marking a mean weight loss of 26.6% and 26.0% over 84 and 88 weeks respectively [93,94]