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Semaglutide has a half-life of approximately one week , meaning it takes around five weeks to reach steady-state levels in your body

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Initial Adjustment Period Most people experience fatigue within the first few days to weeks after starting GLP-1 therapy

"We continue to conclude that the benefits of these medications outweigh their risks when they are used according to the FDA approved labeling," spokesperson Chanapa Tantibanchachai said in an email to NPR