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Tirzepatide (Mounjaro), a dual GIP/GLP-1 receptor agonist, shows dose-dependent nausea rates, ranging from approximately 12-18% at lower doses to higher rates at doses used for weight management, as demonstrated in the SURPASS-2 trial comparing it with semaglutide

doi: 10.1038/s42255-024-00985-1 2

An expanded portfolio of multi-agonists would allow physicians to tailor therapy that targets specific facets of metabolic disease