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This study was limited by having a low number of non-White participants which can limit generalizability, as well as not being adequately powered to evaluate hospitalizations and urgent visits
Retatrutide dosing protocol Retatrutide uses a different titration approach, reflecting its greater potency and triple-receptor activity: Weeks 1-4: 1 mg once weekly (starting dose) Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Week 17 onward: 8-12 mg once weekly (maintenance dose) Some trial protocols use a slightly modified schedule, escalating every four weeks with dose increases of approximately double at each step
A critical aspect of its oncogenicity is its ability to induce chemoresistance
Cell Mol Gastroenterol Hepatol (2015) 11:2840
Long-term Safety and Efficacy: While studies show promising results, the long-term effects and safety of prolonged use are still being evaluated
