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The most significant clinical evidence for retatrutide to date comes from a Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023)
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PMID: 32 TournadreABeaugerM
Eli Lilly has said it will submit orforglipron for FDA approval by the end of this year
Slows gastric emptying for prolonged satiety
While Wegovy is currently FDA-approved for chronic weight management, Mounjaro is approved to treat type 2 diabetes but is often prescribed off-label for weight loss due to its significant impact on weight reduction
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