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Mitochondrial Open Reading Frame of the 12S rRNA Type-c (commonly referred to as MOTs-C) is a mitochondrial derived peptide that plays as essential role in energy metabolism, insulin resistance, inflammatory response, and aging

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The correlative investigations of healthy individuals revealed that eating healthy diets with lots of fruits and vegetables, moderate amounts of dairy, eggs, and fish, and unsaturated fats results in a decreased prevalence of depression (244)

In Depression, Firmicutes (primarily the genera Clostridium, Enterococcus, Lactobacillus , and Faecalibacterium ) and Bacteroidetes (particularly the species Bacteroides and Prevotella ) account for over 90% of the adult gut microbiota (61)