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Ultimately, the activation of GC by NO leads to the stimulation of PGC-1 and NO-mediated mitochondrial biogenesis
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Clinical applications focus on type 2 diabetes characterized by beta-cell failure, early-stage diabetes, and pre-diabetic states, wherein abnormalities in insulin secretion lead to hyperglycemia and metabolic dysregulation (Obakiro et al
Banger KK et al
Br J Pharmacol 95:830834
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