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The covariate models were parameterised as follows for the i th individual: and the effect of drug product strength on the rate of absorption was described as Covariate relationships were described as follows: In the above equations, represents an estimated value for a covariate and represents between-subject variability

The rectal route puts KPV directly at the site of distal colonic inflammation, which aligns with the PepT1 uptake data

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