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It typically peaks during dose escalation and resolves within 1-2 weeks at each new dose level

Endocr Rev

This means a double strike against excess body mass: on one hand, you get rid of existing stores, and on the other, you block the deposition of new ones

This has led to a proliferation of private clinics and practitioners offering so-called booster shots of B12 as a pick-me-up to help decrease fatigue, improve mood, motivation, and provide a feeling of being refreshed even in those without a diagnosed deficiency, also targeting vegans and vegetarians as a cohort at risk of B12 deficiency