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4.7 The products of microbiome (SCFAs) indirectly protect the esophagus from multiple pathways and have potential for the treatment of GERD Microorganisms in the colon are capable of fermenting indigestible food components and consuming prebiotics to produce short-chain fatty acids (SCFAs) (78, 79) The relationship between SCFAs and GERD is not yet clear, but known studies have found that SCFAs have some potential for treating GERD ( Figure 2 )