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Heres how the evidence stacks up when we look at effectiveness by goal: Cognitive performance: Citicoline and alpha-glycerophosphocholine (alpha-GPC) are choline compounds that appear to cross the bloodbrain barrier and support acetylcholine, which is critical for brain function.4 5 6 Citicoline has the strongest trial evidence at 250-500mg/day, while alpha-GPC shows promise but with fewer studies.7 8 Athletic performance: Small preliminary trials suggest alpha-GPC may enhance lower-body power at 600mg/day and support post-exercise recovery at 1,000mg/day.9 10 Liver health: Phosphatidylcholine (PC) is a common supplemental form of choline that helps package and export fats from the liver

Annu Rev Nutr (2005) 25:21535

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