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Ozempic, Mounjaro, and Rybelsus are approved for type 2 diabetes, so prescribing them for weight loss is an off-label use

S., & Romeo, A

Novo Nordisk claims first GLP-1 approval in MASH Novo Nordisk's GLP-1 drugs have been under considerable competitive pressure in the last few months, so the company will be celebrating a first-in-class approval from the FDA for Wegovy in metabolic dysfunction-associated steatohepatitis (MASH)

The key point is that this is the first randomized, placebo-controlled clinical evidence that a GLP-1 receptor agonist may slow the biological processes associated with aging in humans. Michael Corley, PhD Using multiple epigenetic clocks, we saw a broad pattern of slower biological aging in participants treated with semaglutide compared with placebo, including a 9% slowing in the pace of aging measured by DunedinPACE and a significant effect on PCGrimAge, which tracks processes linked to all-cause mortality and age-related disease, the researcher detailed

Diabetes Care 44(11):25892625