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Side effects may include local injection site reactions, gastrointestinal disturbances, hypersensitivity reactions, hemolytic anemia in G6PD-deficient patients, and kidney stone formation in susceptible individuals

Its sequence Aib-His-D-2Nal-D-Phe-Lys-NH incorporates an -aminoisobutyric acid (Aib) N-terminal residue, D-configuration amino acids at positions 3 and 4, and a C-terminal amide, all of which contribute to protease resistance and receptor selectivity

However, when studied, peptides like Receptor Grade IGF-1 LR3 appeared to induce glucose uptake not just through IGF-1 receptor interactions but also independently, possibly via other pathways or receptors

Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death

doi: 10.1016/j.canlet.2018.06.018 128 WangHXieY