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Together with the mentioned above defensive mechanisms, lysosomal and proteasomal systems are also important (15, 111), since to some extent, they are involved in the clearance of poorly degraded AGEs (Figure 5, red arrows 6)

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Ipamorelin's pulsatile profile may better preserve normal GH axis feedback compared to sustained-release compounds

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Furthermore, only four studies reported MCID thresholds, and none performed responder analyses beyond the 50% VAS reduction criterion (Shokri et al., 2021