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A pancreas will stop doing any work at all when injected insulin is needed

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Therapy with a GLP-1 RA or sodium-glucose cotransporter 2 inhibitor (SGLT2 inhibitor) that has proven CV benefit is recommended for initial therapy, with or without metformin based on glycemic needs, in patients with indicators of high-risk or established CV disease

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Excessive pressure pushes the needle deeper, potentially into muscle