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A study revealed that L-methionine supplementation (1.7 g/kg/day, P.O for 8 weeks) was sufficient to produce hyperhomocysteinemia in rats and markedly increased the mean arterial pressure, oxidative stress and mean cardiomyocyte diameter [107]
Journal of Immunology, 187 (3), 1201-1206
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Beyond MC1R-focused investigations, MT1 has also been utilized as an agonist probe across other melanocortin receptor subtypes in in vitro and animal model studies
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