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Measurable density changes are typically not visible to the naked eye yet
Bioengineering 10 (2023)
10.1016/j.freeradbiomed.2017.10.345 105 WangH.ShangY.WangE.XuX.ZhangQ.QianC.et al (2022)
These precedents highlight the need for indication-specific risk assessment and careful differentiation between mechanism-based toxicity and species-specific artifacts
This directly complicates patient screening and enrollment, leads to substantially lower overall expected efficacy compared with patients harboring upstream genetic defects (such as POMC deficiency) [56] , and results in a low statistical success rate in large-scale trials
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