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This progressive deficit leads to insufficient sirtuin activation, mitochondrial respiratory chain dysfunction, and decreased ATP production (Rajman et al., Cell Metab 2018)
Quality of life isn't a soft endpoint
Autoimmune gastritis
Phenome-wide associations In the GWAS catalogue 18 , the index BMI-loss SNP in GLP1R , rs10305420, has been reported as associated with T2D 19,20 , smoking initiation 21 , fasting glucose 20 and haemoglobin A1c (HbA1c) measurements 20
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