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Haemoglobin levels begin rising, and macrocytic anaemia starts resolving

Focus on outcomes tied to objective measures such as improved sperm count, motility, morphology, or reduced DNA fragmentation

Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study

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Food and Drug Administration for the uses discussed here, and much of the available research comes from laboratory and animal studies