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En pacientes previamente tratados con metformina y/o sulfonilureas la adicin de por lo menos 3 aos con GLP1-RA, evidencindose una mejora de marcadores lipdicos como triacilglicridos (-12%), colesterol total (-5%), LDL (-6%) y HDL (+24%) 149

Methods accounting for differences in randomization ratios and study-level cardiovascular risk Due to the asymmetric randomization ratios and patient populations with different cardiovascular risk across the trials, the crude estimates simply aggregating the trials on each of the pooled tirzepatide group and the pooled comparator group could be misleading

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Tirzepatide produced 8.1% weight reduction from baseline ( T -test, p = 9 10 4 ), exceeding Semaglutides 6.0% decrease ( T -test, p = 2.45 10 8 )

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