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The maximum concentrations (C max ) of each dose were 12.3, 48.9, and 141 ng/ml, respectively, and the AUC 0t values were 75.1, 289, and 1930 ng min/ml, respectively

Generally, after renal tubular epithelial cell injury, surviving renal tubular epithelial cells undergo dedifferentiation and proliferation to repair the damage [11]

Chua and coworkers have reported that Sirt7 showed highly specific deacetylase activity on acetylated H3K18 peptide, and that Sirt7 also showed robust and specific H3K18Ac-deacetylase activity on full-length histone H3 in purified poly-nucleosomes 35

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- Claire P