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Each escalation step roughly doubles the previous dose until reaching the 1.8 mg level, after which increases become more modest
It has been studied for insomnia, narcolepsy and opioid withdrawal, but concerns included small, older studies, unclear dosing, limited impurity data and the fact that approved treatments already exist for several of its proposed uses
Intramuscular (IM) B12 injections using hydroxocobalamin, the preferred licensed form in the UK are recommended when: Oral supplementation has failed to correct a documented deficiency The patient has difficulty adhering to daily oral regimens Serum B12 levels remain persistently low despite adequate oral dosing There is clinical evidence of neurological or haematological complications In line with BNF guidance, the standard IM regimen for confirmed deficiency without neurological involvement is a loading course of 1 mg hydroxocobalamin on alternate days for two weeks , followed by maintenance of 1 mg every three months
Important clinical note: GHK-Cu is not FDA-approved to treat, cure, or prevent any specific disease
