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Moreover, mtDNA stress can activate the cGAS-STING-mediated DNA sensing pathway, inducing autophagy-dependent ferroptosis via lipid peroxidation (137)

Rather than taking berberine for this effect, you can take Akkermansia probiotics directly to help populate this strain in your gut

1, 2024, pp

Fornes A et al

Olshansky agrees with that point, and asserts what Johnson's biomarkers say is irrelevant: "What you need in order for any of that information to be useful is evidence to indicate that if you have a biomarker indicating that your biological age is younger than your chronological age, that it will actually make you live longer