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TLC-2716 was administered orally at 1, 5 and 15 mg per kg (body weight) per day (2- to 28-fold the maximum clinical dose based on allometric scaling) for 28 days to young, lean male and female NHPs

7 Comparison with other drugs Some clinical studies have used other metabolic medications and compared their effects on liver diseases to those of GLP-1RAs

Mass spectrometry analysis of metabolitessample preparation The liver, brain, kidney, and lung tissues were homogenized with a pre-chilled BioPulverizer (59012MS, BioSpec) and then placed on dry ice

Hemorrhage was controlled with sterile surgical sponge compresses

At present there are two classes of drug that potentiate the incretin effect as a means of improving glycemic control in type 2 diabetes