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It has been hypothesised, based largely on data from tirzepatide studies, that GIPR agonism may moderate some of the gastrointestinal side effects associated with GLP-1R stimulation
The Documented Application Areas
PMID: 41999297 Guldhammer A et al
In these cases, the pain may come from peripheral trigeminal branch irritation, previous dental work, shingles, scar tissue, muscle spasm, or central sensitization
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