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A practical periconception management approach is as follows: (i) Target achievement: Continue treatment alongside lifestyle intervention until pre-specified weight and metabolic targets are met (e.g., 5%10% weight loss with improvement in IR markers)
Saxenda, known as liraglutide, is another GLP-1 receptor agonist approved for weight loss
Additionally, semaglutide appears to improve insulin sensitivity and reduce cravings for high-calorie foodseffects that reverse after discontinuation
Owing to the rising prevalence of diabetes, obesity is expected to increase the demand for targeted and personalized therapies
[1] In clinical trials, the most frequently reported adverse effects of Zepbound were gastrointestinal in nature, including nausea, diarrhea, vomiting, constipation, and abdominal pain
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