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Dnmt and tet activity assays The Dnmt activity and Tet activity assays were conducted using a Dnmt activity/inhibition assay kit (Epigentek, Farmingdale, NY) and a Tet activity/inhibition direct assay kit (Epigentek, Farmingdale, NY), respectively, following the manufacturers protocols

When oxidative demand approaches the regenerative capacity of nicotinamide adenine dinucleotide (NAD)/ nicotinamide adenine dinucleotide phosphate (NADPH

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