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IL-1 mediates TNF-induced osteoclastogenesis
This second step requires NAD+ and generates NADH, shifting the hepatic redox state toward reduction and impairing mitochondrial ATP production
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The study highlights that PEGylated PLGA nanoparticles, could offer a promising alternative for the safe delivery of tolcapone, maintaining its therapeutic effects while significantly reducing associated hepatotoxicity 129
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