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It assists individuals in establishing genuine expectations and anticipating obstacles
The BMJ
Interestingly, the OB is not only a metabolic sensor but also participates in the control of energy balance: CRISPR gene editing to enhance the excitability of MCs in DIO mice resulted in improved glucose tolerance 34 and these neurons also control the cephalic phase of insulin release 16
Because Wegovy (when approved at its highest dose) produces rapid weight loss and sharper metabolic shifts, this could drive the stronger association by predisposing to optic nerve hypoperfusion through intravascular volume contraction, hypotension with nocturnal dips and autonomic instability. For ophthalmologists, the findings highlight a potential safety signal that warrants further investigation but should be interpreted cautiously
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