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The current thinking is that in many people with obesity, that signal exists but isn't getting through loudly enough, a kind of appetite dysregulation
People exploring hormonal treatment to lose weight often want a single answer, but menopause weight gain usually needs layered care rather than one prescription
Therefore, direct measurement requires that the IGF-1/IGFBP complex be disrupted
Clinical trials that proved fat loss and health benefits used full therapeutic doses in people with obesity not microdosing tirzepatide or semaglutide in already lean athletes
Recovery should be measured by function, strength, resilience, and return to activity, not only by symptom reduction
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