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Non-nutritive sweeteners in moderation and for the short term can be used in place of sugar to aid caloric restriction
AMPK also inhibits lipid biosynthesis by suppressing transcription factor sterol regulatory element-binding protein 1 (SREBP1) and promoting the action of peroxisome proliferator-activated receptor alpha (PPAR), a nuclear receptor that acts to enhance both mitochondrial and peroxisomal FA -oxidation 23
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In the UK, this is included as a special warning and precaution in the Summary of Product Characteristics (SmPC) rather than a formal contraindication
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