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Option 4: combination approach The ATTAIN-MAINTAIN trial data suggests a compelling combination strategy: use injectable tirzepatide to achieve aggressive initial weight loss, then transition to oral orforglipron (once available) for convenient long-term maintenance
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HIMS is sacrificing the oral pill, which existed for all of 48 hours and generated approximately zero meaningful revenue, in the hope of appeasing the FDA enough to keep the injectable compounding business alive
74 This may partly explain the ability of GLP-1RAs to reduce MACE incidence, which has been demonstrated in research
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