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In animal studies, DSIP demonstrated anxiolytic effects, reducing anxiety-like behavior in mice (Shekunova et al., 2002), and lowering plasma corticosterone levels in rats (Kovalzon et al., 1997)

Cost-effectiveness of once daily GLP-1 receptor agonist lixisenatide compared to bolus insulin both in combination with basal insulin for the treatment of patients with type 2 diabetes in Norway

Severe depression or anxiety, or thoughts of self-harm

Statistical analysis Statistical analyses were performed using GraphPad Prism 10.5.0 (GraphPad Software, San Diego, CA, USA)

How Semaglutide Works in the Body To understand semaglutide, it helps to know what GLP-1 hormones do