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Moreover, a natural compound of the tetraterpene group from tomatoes, lycopene (10 mg/day, P.O for 2 months), was reported to significantly increase the ratio of serum TAC to MDA in patients with type 2 diabetes [149]
A modest increase in resting heart rate was also observed in some participants receiving higher doses, which is an anticipated effect of glucagon receptor agonism and warrants ongoing monitoring in future trials
For mild headaches or fever, acetaminophen remains a first-line alternative
Synthetic compounds such as dimethyl fumarate (DMF) and its major metabolite monomethyl fumarate are synthetic compounds that have been proven to activate the NRF2 pathway [458]
Some patients experience minimal fatigue, while others find it significantly impacts their daily activities, particularly when starting treatment or following dose increases
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