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Moreover, phospho-BCL-XL (Ser62) stabilizes G2 arrest by binding to and co-localizing with Cdk1 (cdc2) in nucleolar structures to avoid rapid nucleolar disassembly associated with mitosis onset, playing an unexpected role in the G2 phase checkpoint downstream of DNA damage distinct from its anti-apoptotic function 22
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In addition, as semaglutide is not officially approved for chronic weight management, changes in facial appearance are not listed in the FDA label as adverse events [88]
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