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In certain cases, supplementation may not be advised

doi: 10.1016/j.trsl.2020.03.012, Summary Keywords aging, exercise, L-citrulline, leucine, musclevasculature, cognitive frailty, successful aging, neurovascular coupling Citation Lin X, Zhang Y, Pu J and Peng Y (2026) Targeting musclevasculature crosstalk in aging through the integrative roles of L-citrulline, leucine, and exercise: focus on muscle metabolism, vascular function, and sarcopenia prevention

He suspects pharmaceutical companies likely examined popular injectable peptides but opted not to pursue them because of weak results or safety concerns

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