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Free radicals damage cells, destabilize the immune system and can contribute to the development of serious health problems

Some trials involved split dosing twice per week

Halminen J, Sattar N, Rawshani A et al (2022) Range of risk factor levels, risk control, and temporal trends for nephropathy and end-stage kidney disease in patients with type 1 and type 2 diabetes

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On the other hand, sodium-glucose cotransporter 2 (SGLT2) inhibitors lower blood glucose levels by blocking renal glucose reabsorption, which reduces glucotoxicity, improves -cell function, and increases insulin sensitivity [163]