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Doxorubicin-GSH adduct formation kinetics are thermodynamically estimated from its reduction potential, while the remainder of the model is parameterised using oxygen consumption rate data, indicative of hydroquinone auto-oxidation

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Additionally, Legumain, a cysteine protease known for its role in promoting ferroptosis by interacting with the ferroptosis inhibitor GPX4, is being investigated as a potential therapeutic target and an early diagnostic marker for IRI-AKI [80]