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Case 3 experimented an initial improvement in weight and glycaemic control but with later regain of weight and a deterioration of glycated haemoglobin

In the Novo Nordisk-funded study, published on 22 October 2025, researchers from University College London (UCL) analysed data from the SELECT trial (published in 2023) of 17,604 people from 41 countries aged 45 years and over, who were overweight and had cardiovascular disease (CVD) but did not have diabetes

The compound has been evaluated in multiple preclinical models for its role in modulating adipose tissue and lipid metabolism without mimicking the full spectrum of hGH activity (Heffernan et al