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Valerian root has been shown to be effective in treating sleep disorders in some clinical trials but typically at higher doses than that in Mighty Night.6 7 Research conducted on combination herbal therapies has also had mixed results.8 A note of caution: the ceramides are from a wheat source, and while they are certified gluten-free, they may not be appropriate for those with a wheat allergy since gluten and wheat allergies are not one and the same