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patients should be instructed to seek immediate medical attention for severe, persistent abdominal pain
Tirzepatide the FDA label directs initiation at 2.5 mg once weekly, with escalation in 2.5 mg steps at intervals of at least four weeks to a maximum of 15 mg weekly
Medical Assessment
The Swedish Obese Subjects trial (the gold standard) demonstrated that gastric bypass and sleeve gastrectomy produced 17-23% sustained weight loss over 10-20 years
The case reports involved patients aged 56 and 75, but whether age is a risk factor or simply reflects the demographics of semaglutide users is unclear
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