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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation
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The compound has attracted significant interest in preclinical research for its effects on adipocyte metabolism, body composition, and muscle function in animal models
Methylcobalamin can be the better choice for patients with the MTHFR gene variant, certain liver or kidney concerns, or anyone who has had cyanocobalamin shots and didn't feel a noticeable response
