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269 These findings illustrate that PERK signaling exerts dose-, duration-, and context-dependent effects, complicating efforts to therapeutically manipulate this pathway
[2] Sekhar RV, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, Jahoor F
A large Swedish cohort study found a dose-response relationship, indicating that higher antibiotic use in pregnancy or infancy is associated with greater ADHD risk, possibly through microbiota disruption and altered GBA signaling [97]
A lower GSH:GSSG ratio may indicate increased oxidative burden, environmental stress exposure, metabolic strain, or impaired recovery capacity
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