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Appointment length: 4-8 hours

A 2025 systematic review identified 36 studies from 1993 to 2024, including 35 preclinical studies and only 1 clinical study

A recent meta-analysis of 12 observational studies found that higher dietary intake of vitamin B 12 was associated with a 23% lower risk of depression compared to lower intakes, but stratifying the data revealed a significant protective association in females, not in males (99)

Vitamin B12 injections are different from oral supplements because they are absorbed directly into the bloodstream, allowing the body to use the nutrient more efficiently

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