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Because IGF-1 LR3 bypasses the pituitary and GH entirely, none of the normal negative feedback systems moderate its effect once injected
J.KapoorR.DhawanG.LaraP
Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity - a non-randomized three-armed controlled trial
However, it appears that if people taking the drugs stop, most regain the weight they lost and the health problems that come with weight gain
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