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In 2021, semaglutide 2.4 mg became the most-effective GLP-1 RA approved for obesity management with 14.9% mean WL at 68 weeks vs

In markets where there is state/PMI reimbursement of GLP-1 treatment for obesity (eg the US), retatrutide is likely to be reserved as a second-line GLP-1 for those who have failed to lose sufficient weight with a cheaper alternative (such as semaglutide or tirzepatide)

[105] [102] [106] Several other applications to sell generic versions have been made, but not yet approved, including by Aspen Pharmacare, Sandoz, Taro Pharmaceuticals and Teva Pharmaceuticals

This policy ensures patients can explore treatment options with confidence, knowing they will not incur unnecessary costs if GLP-1 therapy is not suitable

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