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Abbreviations GLP-1: Glucagon-like peptide 1 GIP: Glucose-dependent insulinotropic polypeptide GLP-1R: Glucagon-like peptide 1 receptor GIPR: Glucose-dependent insulinotropic polypeptide receptor ASCVD: Atherosclerotic cardiovascular disease HF: Heart failure HFpEF: Heart failure with preserved ejection fraction HFrEF: Heart failure with reduced ejection fraction T2DM: Type 2 diabetes mellitus EF: Ejection fraction LVEF: Left ventricular ejection fraction LVEDV: Left ventricular end-diastolic volume LVESV: Left ventricular end-systolic volume LVSV: Left ventricular stroke volume CO: Cardiac output CI: Cardiac index BSA: Body surface area LVIDs: Left ventricular internal diameter in systole LVIDd: Left ventricular internal diameter in diastole LVFS: Left ventricular fractional shortening LVAWTs: The thickness of the left ventricular anterior wall in systole LVAWTd: The thickness of the left ventricular anterior wall in diastole LVPWTs: The thickness of the left ventricular posterior wall in systole LVPWTd: The thickness of the left ventricular posterior wall in diastole LV: Left ventricular mass RWT: Relative wall thickness LVRi: Left ventricular remodelling index AngII: Angiotensin II Veh: Vehiculum Lira: Liraglutide TZP: Tirzepatide ECG: Electrocardiography References Ryan DH, Lingvay I, Colhoun HM, Deanfield J, Emerson SS, Kahn SE, et al

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The plateau represents the point where tirzepatide appetite suppression and your body defensive mechanisms reach equilibrium